\ Gamze Torun Köse
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Gamze Torun Köse

Prof. Dr.
Bölüm Başkan Yardımcısı

1617 B502

AD SOYAD/ÜNVAN AKADEMİK BİLGİLER İLETİŞİM
    Gamze Torun Köse Prof.Dr. —————– Bölüm Başkan Yardımcısı —————– Eğitim Durumu Ph.D.: Biyoteknoloji, ODTÜ (University of Texas, MD Anderson Cancer Center) M.Sc.: Biyoteknoloji, ODTÜ B.Sc.: Biyoloji, ODTÜ   Araştırma Alanı (Anahtar Kelimeler) Kemik, Kıkırdak, Sinir Doku Mühendisliği Kök Hücre Çalışmaları (Kemik İliği, Adiposit, Amniotik, Dental Folikül, Dental Pulpa, Dental Jerm) Mikro/nanoşekillendirilmiş Biyobozunur Polimerler İlaç Salım Sistemleri Sert Doku Onarımı Yüzey Modifikasyonu Ofis B502 Telefon +90 216 578 0617 E-Posta gamzekose@yeditepe.edu.tr Web Sayfası http://yuteg.yeditepe.edu.tr/
LABORATUVAR ARAŞTIRMA - PROJE
Biyomalzeme ve Doku Mühendisliği Laboratuvarı  
  1. D.Yücel (Yürütücü), G.Torun Köse (Danışman), V.Hasırcı, Polimerik hücre taşıyıcıların topografisinin ve meningeal hücrelerin mezenkimal kök hücre farklılaşması üzerine etkileri, Tübitak 3501 Kariyer 113S870, 2014-2017
  2. F.N.Kök (Yürütücü), K.Kazmanlı, G.Torun Köse (Araştırmacı), M.Ürgen, The Growth of Magnesium Substituted Hydroxyapatite on (Ti,Mg)N Thin Films and Investigation of their Potential as Hard Tissue Implant Material, TÜBİTAK 1001 MAG 112M339, 2012-2014
  3. H.Çimenoğlu (Yürütücü),  M.Baydoğan, N.G.Karagüler, G.Torun Köse (Danışman), Formation of a Bioactive, Antibacterial and Microporous Oxide Layer on Titanium and Titanium Alloys for Biomedical Purposes, TÜBİTAK 1001 111M517, 2012-2014
  4. T.Beyzadeoğlu (Yürütücü), K.Yüksel, Ö.Karabıyık, F.Altıntaş, A.İvkoviç, C.H.Evans, R.M.Porter, G.Torun Köse (Araştırmacı), Molecular investigation of the inhibition of bone formation after spongious allografting of the MSC isolated from bone and adipose tissues, TOTBİD (Association of Turkish Orthopedy and Traumatology ), 2011-2012
  5. M.Ramazanoğlu (Yürütücü), K.A.Schlegel, G.Torun Köse (Araştırmacı),  The Effect of a Biodegradable Polyethylenglycol-Gel (MX10™) on the Delivery and Osteogenic Differentiation of Autologous Tooth Germ Derived Stem Cells (TGSCs) in a Porcine Model, German ITI (International Team for Implantology) Research Grant, 2011-2013
  6. G.Torun Köse (Yürütücü), M.Ramazanoğlu, O. Karabıyık, A.C.Çalıkoğlu, J.Svadobova, T. Sedlačik, V. Proks, H. Studenovska, Biodegradable polypeptide-based hydrogels for soft tissue regeneration, Tübitak Joint Research and Development Project, 2011-2013
  7. G.Torun Köse (Yürütücü), A.C.Çalıkoğlu, Cartilage tissue engineering on PCL-PLLA scaffolds by using dental jerm stem cells, TÜBİTAK 1002, 2011-2012
  8. V.Hasırcı (Yürütücü), G.Torun Köse (Araştırmacı), K.Ulubayram, K.Şerbetçi, H.Kenar, D.Yücel, N.Hasırcı, Center of Excellence for Biomaterials and Tissue Engineering, State Planning Institute Project (DPT), 2010-2013
  9. M.Karahan (Yürütücü), G.Torun Köse (Danışman), A.Işın Doğan Ekici, Y.M.Yeşim Ünlüçerçi,  “Diz ekleminin akut travmatik osteokondral defektlerinde intraartiküler askorbik asit enjeksiyonunun etkisi”, TÜBİTAK 1002, 2008-2008
  10. G.Torun Köse (Yürütücü), S.Bucak, Muzaffer Değertekin, E.Can, ALVİMED, “İlaç Salan Biyobozunur Polimerik Stent Üretimi”, SAN-TEZ, 00155.STZ.2007-2, 2007-2010
  11. V.Hasırcı (Yürütücü), G.Torun Köse (Araştırmacı), N.Hasırcı, K.Ulubayram, K.Şerbetçi, H.Kenar, D.Yücel, “pH ve sıcaklığa duyarlı, akıllı  nanobiyomateryallerin kıkırdak doku mühendisliğinde kullanımı ve hücre bağlanma sürecinin nano düzeyde incelenmesi”, BAP– 01.08.DPT2003(06)K120920/20 , 2006-2008, 2005-2008
  12. V.Hasırcı (Yürütücü), G.Torun Köse (Araştırmacı), N.Hasırcı, K.Ulubayram, K.Şerbetçi,METUNANOBIOMAT- ODTÜ’de Nanobiyomateryal Araştırmaları Birimi Geliştirilmesi, TÜBİTAK- TBAG 105T508, 2005-2008
  13. Marie-Curie RTN-FP6 BioPolySurf (Project Director J.Carlos Rodriguez-Cabello, Spain) G.Torun Köse (Araştırmacı), “Engineering advanced polymeric surfaces for smart systems in biomedicine, biology, material science and nanotechnology: A cross-disciplinary approach of Biology, Chemistry, and Physics”, 2004-2009
  14. EXPERTISSUES- FP6 European Commission CORDIS Framework Programme Project involving 13 European countries and 20 groups (Project Director R.Reis, Portugal) G.Torun Köse (Araştırmacı), “Novel Therapeutic Strategies for Tissue Engineering of Bone and Cartilage Using Second Generation Biomimetic Scaffolds”, 2004-2009
  15. G.Torun Köse (Yürütücü), V.Hasırcı, D.Yücel, H.Kenar, Study of the influence of micropatterned polymeric PHBV8-PLLA films on the growth and proliferation of neural tissues and molecular approaches in nerve tissue growth : in vitro neural  tissue engineering, TÜBİTAK-SBAG-2723, 2004-2006
  16. F.Korkusuz (Yürütücü), G.Torun Köse (Araştırmacı), A.Özkul, Y.Soysal, T.Özdemir, C.Yıldız, V.Hasırcı, Tissue engineered cartilage on collagen and PHBV matrices, TÜBİTAK-MİSAG-158, 2000-2002
  17. G.Torun Köse (Araştırmacı), F.Korkusuz, V.Hasırcı (Yürütücü), Bone tissue generation on biodegradable polymeric scaffolds, METU Graduate School of Natural and Applied Sciences Project (Project number: AFP-2000-07-02-00-07), 1998-2002
 
SEÇİLMİŞ YAYINLAR VE AKTİVİTELER
Yayınlar  
  1. E.Can, S.Bucak, E.Kınacı, A.Ceren Çalıkoğlu, G.T.Köse, Polybutylene Succinate (PBS) - Polycaprolactone (PCL) Blends Compatibilized with Poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (PEO-PPO-PEO) Copolymer for Biomaterial Applications, Polymer plastics technology and engineering, (accepted), 2014.
  2. T.Endogan, A.Kızıltay, G.T.Köse, N.Comunoglu, T.Beyzadeoglu, N.Hasirci, Acrylic Bone Cements: Effects of the Poly(methyl methacrylate) Powder Size and Chitosan Addition on Their Properties, J.of Applied Polymer Science, DOI: 10.1002/app.39662, 2013.
  3. P. Selcan Güngör Özkerim, Timuçin Balkan, Gamze Köse, A.Sezai Saraç, Fatma N. Kök, Incorporation of growth factor loaded microspheres into polymeric electrospun nanofibers for tissue engineering applications, Journal of Tissue Engineering and Regenerative Medicine, DOI: 10.1002/jbm.a.34857 2013.
  4. B.Yenigün, B.Özpolat, G.T.Köse, Response of CD44+/CD24-/low breast cancer stem/progenitor cells to tamoxifen and doxorubicin induced autophagy, International J.of Molecular Medicine, DOI: 10.3892/ijmm.2013.1342, 2013.
  5. A.B.Ertan, P.Yılgor, B.Bayyurt, Ayşe Ceren Çalıkoğlu, Ç.Kaspar, F.N.Kök, G.T.Köse*(corresponding author), V.Hasirci, Effect of Double Growth Factor Release on Cartilage Tissue Engineering, Journal of Tissue Engineering and Regenerative Medicine, 7(2):149-60. doi: 10.1002/term.509, 2013
  6. S.Öksüz, E.Ülkür, O.Öncül, G.Torun Köse, Z.Küçükodacı, M.Urhan, The Effect of Subcutaneous Mesenchymal Stem Cell Injection on Stasis Zone and Apoptosis in an Experimental Burn Model, Plastic and Reconstructive Surgery, 131 (3), 463-471, 2013.
  7. M.Ramazanoglu, R.Lutz, P.Rusche, L.Trabzon, G.T.Kose, C.Prechtl, K.A.Schlegel, Bone response to biomimetic implants delivering BMP-2 and VEGF: An immunohistochemical study, Journal of Cranio-Maxillo-Facial Surgery, Vol.41 (8), 826-835, DOI: 10.1016/j.jcms.2013.01.037, page 105, 2013
  8. C.Sever, F.Uygur, G.Torun Köse, M.Urhan, A.Hahoğlu, Y.Kulahcı, S.Öksüz, S.Cihan, O.Omer, Prefabrication of vascularized bone graft using an interconnected porous calcium hydroxyapatite ceramic in presence of vascular endothelial growth factor and bone marrow mesenchymal stem cells: Experimental study in rats, Indian Journal of Plastic Surgery, 45(3), 444-452, 2012.
  9. Ö.Karadas, D.Yücel, H.Kenar, G.T.Köse, V.Hasırcı, Collagen scaffolds with in situ-grown calcium phosphate for osteogenic differentiation of Wharton's jelly and menstrual blood stem cells, Journal of Tissue Engineering and Regenerative Medicine, 2012 (in press) doi: 10.1002/term.1555.
  10. T.Beyzadeoglu, G.T.Köse, A.I.Ekici, H.Bekler, C.Yilmaz, Cytotoxicity of local anesthetics to rats' articular cartilage: an experimental study, Acta Orthopaedica et Traumatologica Turcica, 46(3):201-207, 2012
  11. E.Aydemir, O.F.Bayrak, F.Sahin, B.Atalay, G.Torun Kose, M.Ozen, S.Sevli, A.B.Dalan, M.E.Yalvac, T.Dogruluk, U.Türe, Characterization of cancer stem-like cells in chordoma, J Neurosurg, 116(4):810-820, 2012.
  12. B.Demirbag, P.Yilgor Huri, G.Torun Kose, A.Buyuksungur, V.Hasirci, Advanced Cell Therapies With and Without Scaffolds, Biotechnology Journal, 6:12, 1437-1453, 2011
  13. E.Can, G.Üdenir, A.İ.Kanneci, G.Torun Kose, S.Bucak, Investigation of PLLA/PCL Blends and Paclitaxel Release Profiles, AAPS PharmSciTech, 12:4, 1442-1453, 2011
  14. H.Kenar, G.Torun Kose, M.Toner, D.L. Kaplan, V.Hasirci, A 3D Aligned Microfibrous Myocardial Tissue Construct Cultured under Transient Perfusion, Biomaterials, 32:23, 5320-5329, 2011.
  15. H.Cimenoglu, M.Gunyuz, G.Torun Köse, M.Baydogan, F.Ugurlu, C.Sener, Micro-Arc Oxidation of Ti6Al4V and Ti6Al7Nb Alloys for Biomedical Applications, Materials Characterization, 62:3, 304-311, 2011.
  16. D.Yücel, G.T.Köse, V.Hasırcı, Tissue Engineered, Guided Nerve Tube Consisting of Aligned Neural Stem Cells and Astrocytes, Biomacromolecules, 11, 3584–3591, 2010.
  17. H.Kenar, G.T.Köse, V.Hasırcı, Design of a 3D Aligned Myocardial Tissue Construct From Biodegradable Polyesters, J.Mater.Sci.Mater.Med., 21(3): 989-997, 2010
  18. D.Yücel, G.T.Köse, V.Hasırcı, Polyester Based Nerve Guidance Conduit Design, Biomaterials 31(7):1596-1603, 2010
  19. M.E.Yalvac, M.Ramazanoglu,A.A.Rizvanov, F.Sahin, O.F.Bayrak, U.Salli, A.Palota´s, G.T. Köse, Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: implications in neo-vascularization, osteo-, adipo- and neurogenesis, Pharmacogenomics Journal, 10, 105-113,  2010
  20. C.Sever, F.Uygur, Y.Külahçı, G.Torun Köse, M.Urhan, Z.Küçükodacı, G.Uzun, O.İplikçioğlu, T.Çaycı, Effect of hyperbaric oxygen therapy on bone prefabrication in rats, Acta Orthopaedica et Traumatologica Turcica, 44(5):403-409, 2010.
  21. N. Ozturk,  A. Girotti,  G. T. Köse,  J. C. Rodríguez-Cabello,  V. Hasirci, Development of A Novel Method For Dynamic Cell Culturing And Its Application To Micropatterned, ELP-Modified P-Nipam Scaffolds, Biomaterials, 30(29):5417-26, 2009
  22. B.Başmanav, G.T.Köse, and V.Hasirci, Sequential Growth Factor Delivery From Complexed Microspheres For Bone Tissue Engineering, Biomaterials, Vol.29, 4195-4204, 2008
  23. H.Kenar, G.T.Köse, and V.Hasirci,  Tissue engineering of bone on micropatterned biodegradable polyester films,  Biomaterials  Vol.27, 885-895,  2006
  24. G.T.Köse*, F.Korkusuz, A.Özkul, Y.Soysal, T. Özdemir, C.Yildiz, and V.Hasirci, Tissue engineered cartilage on collagen and PHBV matrices, Biomaterials Vol.26, 5187-5197, 2005
  25. S.Ber, G.T.Köse, and V.Hasirci, Bone tissue engineering on patterned collagen films: An in vitro study, Biomaterials, Vol. 26, Iss. 14, 1977-1986, 2005
  26. G.T.Köse, F.Korkusuz, P.Korkusuz, and V. Hasırcı, In vivo tissue engineering of bone using Poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) and collagen scaffolds, Tissue Engineering,  Vol.10, 7/8, pg. 1234-1250, 2004
  27. G.T.Köse, F.Korkusuz, P.Korkusuz, N.Purali, A.Özkul, and V. Hasırcı, Bone generation on PHBV matrices: an in vitro study,  Biomaterials, Vol.24, pg. 4999-5007, 2003
  28. G.T.Köse, H. Kenar, N. Hasırcı and V. Hasırcı, Macroporous Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) matrices for bone tissue engineering, Biomaterials, Vol. 24, 1949-1958, 2003
  29. G.T. Köse, F. Korkusuz, S.Ber, and V. Hasırcı, Poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) Based Tissue Engineering Matrices, Journal of Materials Science: Materials in Medicine, Vol.14, pg. 121-126, 2003
  30. A.Tezcaner, G.T. Köse and V. Hasırcı, Fundamentals of Tissue Engineering: Tissues and Applications, Technology and Health care, Vol.10 Iss. (3,4), pg. 203-216, 2002
  31. G.T. Köse, A. Tezcaner and V. Hasırcı, Fundamentals of Tissue Engineering: Carrier Materials and an Application, Technology and Health care, Vol.10 Iss. (3,4), pg. 187-201, 2002
  32. G.T. Köse, M.Y. Arıca and V. Hasırcı, Low-Molecular-Weight Heparin-Conjugated Liposomes with Improved Stability and Hemocompatibility, Drug Delivery, 5, 257-264, 1997
  Kitap Bölümleri  
  1.     A.Ivkovic, A. Vukasovic, T.Beyzadeoglu, G.T.Köse, Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation, M.N.Doral and J.Karlsson (ed.), Clinical Relevance of Gene Therapy and Growth Factors in Sports Injuries, Springer, 2014
  2.     M.Ramazanoglu, K.A.Schlegel, G.Torun Köse, Potential use of dental stem cells for craniofacial tissue regeneration in  Stem Cells and Regenerative Medicine: Progress and Challenges, K.Turksen, Springer, DOI 10.1007/978-1-4614-8066-2, page 105, 2014
  3.     D.Yucel, I.A.Kanneci, D.Arslantunali, G.Torun Kose, V.Hasirci, Spinal Cord Injury: Tissue Engineering Using Neural Stem Cells, in: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury, M.A. Hayat (ed.), Tumors of the Central Nervous System, Volume 10, DOI 10.1007/978-94-007-5681-6_29, Springer Science+Business Media Dordrecht, 2013
  4.     G.T. Köse and V.Hasırcı, Cartilage Tissue Engineering, in: Biomaterials: From Molecules toEngineered Tissues, N.Hasırcı and V.Hasırcı, Kluwer Plenum, London, UK, pp. 317-329, 2004
  5.     G.T. Köse and V. Hasırcı, Polymeric Biodegradable Hard Tissue Engineering Applications, in: Tissue Engineering and Biodegradable Equivalents: Scientific and Clinical Applications, D.L. Wise, Marcel Dekker, Inc., U.S.A, pp.301-315, 2002
  Ödüller  
  1. İTÜ Fen Bilimleri Enstitüsü en başarılı tez ödülü, Perihan Selcan Güngör Özkerim, Doç. Dr. Fatma Neşe Kök (Danışman), Prof. Dr. Gamze Torun
Köse (eş-danışman), Design of Bioactive Scaffold System for Hard Tissue Engineering
  1.       35. Ulusal Türk Plastik Rekonstrüktif ve Estetik Cerrahi Derneği (TPRECD), 2013 Asistan Bildiri Yarışması Deneysel Kategori İkinciliği, 2013
  2.       TUBA destekli LOreal Türkiye Genç Bilim Kadınlarına Destek Bursu, 2011
  3.       FABED Eser Tümen Üstün Başarılı Genç Bilim İnsanlarına Araştırma Ödülü, 2011
  4.       20. Ulusal Elektron Mikroskopi Kongresi (Uluslararası Katılımlı) Prof.Dr. Türkan Erbengi Araştırma Ödülü (jüri özel ödülü), 2011
  5.       ODTÜ 2008-2009 Akademik Yılı En İyi Doktora Tez Ödülü sahibi Deniz Yücelin eş-danışmanı sertifikası, 2010
  6.       ODTÜ 2008-2009 Akademik Yılı En İyi Doktora Tez Ödülü sahibi Halime Kenarın eş-danışmanı sertifikası, 2010
  7.       32. Ulusal Türk Plastik Rekonstrüktif ve Estetik Cerrahi Derneği (TPRECD), 2010 Asistan Bildiri Yarışması Deneysel Kategori Birinciliği, 2010
  8.       Prof. M. Parlar Vakfı tarafından verilen ODTÜ de yılın en iyi PhD tezi ödülü, 2002.
10.BIOMED 2002 Bilimsel Komitesi tarafından verilen En İyi Poster Ödülü, Poster başlığı “ Guided Tissue Engineering on Semisynthetic Polymer Surfaces” H.Kenar, G.T.Köse, V.Hasırcı, 2002. 11.Biyomateryal Avrupa Topluluğu (ESB 2002) tarafından verilen Genç Bilim Adamı Bursu, 2002. 12.Prof. M. Parlar Vakfı tarafından verilen ODTÜ de yılın en iyi MSc tezi ödülü, 1997.  
 
Ders kodu GBE 212 GBE 216 GBE 432 GBE 433 GBE 492 BTEC 533 BTEC 535 BTEC 610   Dersin adı Classical and Molecular Genetics Classical and Molecular Genetics Laboratory Cell and Tissue Culture Biomaterials Engineering Project Advanced Biomaterials Mammalian Tissue Engineering Tissue Engineering Applications  

Yeditepe Üniversitesi, Genetik ve Biyomühendislik Bölümü,
26 Ağustos Yerleşimi, Kayışdağı Cad. 34755 Ataşehir, İstanbul

(216) 578 0619 dileks@yeditepe.edu.tr